2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-136813
    Multitarget AD inhibitor-1 2205015-77-4 98%
    Multitarget AD inhibitor-1 is a selective and reversible butyrylcholinesterase (BuChE) inhibitor with IC50s of 7.22 μM and 1.55 μM for hBuChE and eqBuChE (BuChE from equine serum), respectively. Multitarget AD inhibitor-1 inhibits β-secretase (IC50hBACE-1=41.60 μM), amyloid β aggregation (IC50Aβ=3.09 μM), tau aggregation. Multitarget AD inhibitor-1, a diphenylpropylamine derivative, has the potential for multifunctional disease-modifying anti-Alzheimer’s research.
    Multitarget AD inhibitor-1
  • HY-136842
    Oxetorone fumarate 34522-46-8 98%
    Oxetorone fumarate is a non-selective, orally active serotonin antagonist. Oxetorone fumarate is an antimigraine agent.
    Oxetorone fumarate
  • HY-136860
    (R)-Venlafaxine 93413-46-8 98%
    (R)-Venlafaxine is the R-enantiomer of venlafaxine (HY-B0196), an orally active and potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. (R)-Venlafaxine can be utilized in antidepressant research.
    (R)-Venlafaxine
  • HY-13694R
    Methionine (Standard) 348-67-4
    Methionine (Standard) is the analytical standard of Methionine. This product is intended for research and analytical applications. Methionine (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.
    Methionine (Standard)
  • HY-137088
    Imiclopazine 7414-95-1 98%
    Imiclopazine is a phenothiazine derivative with with psychomotor stabilizing properties, antiaggressive and antiemetic effects.
    Imiclopazine
  • HY-137107
    Radafaxine 192374-14-4 98%
    Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion.
    Radafaxine
  • HY-137152
    8-Aminoclonazolam 71368-66-6 98%
    8-Aminoclonazolam is a benzodiazepine and clonazolam metabolite.
    8-Aminoclonazolam
  • HY-13716R
    Noscapine (Standard) 128-62-1
    Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier[4].
    Noscapine (Standard)
  • HY-137180
    Naloxonazine 82824-01-9 98%
    Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function.
    Naloxonazine
  • HY-13720S
    Pergolide-d7 hydrochloride 98%
    Pergolide-d7 hydrochloride is deuterated labeled Pergolide (HY-13720). Pergolide (LY127809 (free base)) is an ergot-derived orally active dopamine receptor agonist. Pergolide can be used for Parkinson disease research.
    Pergolide-d7 hydrochloride
  • HY-137332
    N-Methylspiroperidol 87539-19-3 98%
    N-Methylspiroperidol is a D2 receptor antagonist. N-Methylspiroperidol can be labeled as [18F]N-Methylspiroperidol and used in PET (Positron Emission Tomography) to study how it binds to the 5-HT2C receptor and the competition and effects of neurotransmitters like dopamine on these receptors.
    N-Methylspiroperidol
  • HY-137386
    2-Oxo-3-hydroxy-LSD 111295-09-1 98%
    2-Oxo-3-hydroxy-LSD is a metabolite of Lysergic acid diethylamide.
    2-Oxo-3-hydroxy-LSD
  • HY-137532
    7-Hydroxyquetiapine 139079-39-3 98%
    7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine[1].
    7-Hydroxyquetiapine
  • HY-137557
    Florzolotau 1565797-16-1 98%
    Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used to detect Alzheimer's disease (AD) and other tau proteinopathies. Its binding sites are located in the β-helix of the paired helical filaments (PHFs) and straight filaments (SFs) of the tau protein, as well as in the C-shaped cavity of the SFs. In addition, APN-1607 can bind to the intraneuronal inclusions in Alzheimer's disease (AD), primary age-related tauopathy (PART), and posterior cortical atrophy (PCA). Florzolotau is expected to be used in PET imaging research of neurological diseases, especially tau proteinopathies.
    Florzolotau
  • HY-13788B
    LY 344864 hydrochloride 1217756-94-9 98%
    LY 344864 hydrochloride is a selective, orally active 5-HT1F receptor agonist with a Ki of 6 nM. LY 344864 hydrochloride is a full agonist producing an effect similar in magnitude to serotonin itself. LY 344864 hydrochloride can cross the blood brain barrier to some extent.
    LY 344864 hydrochloride
  • HY-137979
    Flunitrazolam 2243815-18-9 98%
    Flunitrazolam is an orally active designer Benzodiazepine. Flunitrazolam is biologically toxic, class in psychoactive substances.
    Flunitrazolam
  • HY-137988
    Palvanil 69693-13-6 98%
    Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects.
    Palvanil
  • HY-138058
    AF-CX 921 77946-49-7 98%
    AF-CX 921 is a strong antiepileptic drug.
    AF-CX 921
  • HY-138060
    Moperone hydrochloride 3871-82-7 98%
    Moperone hydrochloride is a dopamine D2-receptor antagonist, exhibiting therapeutic efficacy in the management of psychiatric disorders.
    Moperone hydrochloride
  • HY-138077
    LSM-775 maleate 101896-80-4 98%
    LSM-775 maleate is a lysergamide.
    LSM-775 maleate
Cat. No. Product Name / Synonyms Application Reactivity